The mole is the fundamental SI unit for the amount of substance, defined by the Avogadro constant (6.02 x 10^23 particles). It serves as the critical bridge between the atomic scale and macroscopic measurements, enabling the calculation of reacting masses via the relationship Mass = Moles x Molar Mass. Mastery involves applying stoichiometry to balanced equations to determine theoretical yields, identifying limiting reactants, and calculating concentrations in solutions. This quantitative framework underpins all analytical chemistry and industrial process design.
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