Chemistry A-Level
amide formation
What amide formation means in Chemistry A-Level, as defined for AQA.
Definition of amide formation
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Reference: AQA
Ammonia or a primary amine attacks the carbonyl carbon of an acyl chloride or an anhydride, and the chloride or carboxylate is eliminated, so the product keeps the C=O and gains a nitrogen.
Topics that use amide formation
- Nucleophilic properties (A-level only) (AQA A-Level)
Related terms
- addition-elimination
- anhydride versus acyl chloride
- attack at a δ⁺ carbon
- attraction to negative surfaces
- Bond enthalpy
- cationic surfactant
- controlling the product
- further substitution
Using amide formation in the exam
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